Winship Biostatistics and Bioinformatics Shiny Server

Biostatistics and Bioinformatics Applications for Cancer Research

Integrated Genomic Analysis of:
- Genes using GISPA
- Samples using SISPA
- Gene Outliers using G-OPEA
Clustering Analysis with NOJAH
Supervised Principle Component Analysis with GAC
Survival Analysis with CASAS
Exploratory Analysis with shinyEA

Defining Samples with Signatures:

Sample Integrated Set Profile Analysis (SISPA)

How to define samples with a gene signature that is based on combined changes in expression, copy number, methylation, and variant allele frequencies?

With SISPA, you can use:

Any combination of molecular data types
As few as five samples

With SISPA, you can define:

Samples with molecular changes based on a pathway/network
Cell lines with gemonic and IC50 changes

http://bbisr.shinyapps.winship.emory.edu/shinySISPA/

Publication:
Kowalski, et al. (2016) Gene integrated set profile analysis: a context-based approach for inferring biological endpoints. Nucleic Acids Res. 2016 Apr 20; 44(7): e69.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838358/